• تاريخ التحديث: 06 جمادى الأخرة 1440 - الموافق 11 شباط/فبراير 2019.
• المصدر: (Web of Science (ISI.
• نوع الأوراق: (Document Type = (ARTICLE OR REVIEW.
• Medicinal Chemistry
• تغطي هذه المجموعة من الأوراق الموارد التي تهتم على عزل ودراسة المستخلصات ذات الإمكانيات العلاجية. وتشمل مواضيع مثل: العلاقات الوظيفة التركيبية والكمية، التوصيف التركيبي والعضوي للمركبات الطبيعية، التقنيات الكيميائية والتحليلية المستخدمة في تصميم الأدوية.  

1. Ethnopharmacological uses, phytochemistry, biological activities of Debregeasia salicifolia: A review
   - By: Almubayedh, Hanine; Ahmad, Rizwan
   - JOURNAL OF ETHNOPHARMACOLOGY
   - Volume: 231   Pages: 179-186  Published: MAR 1 2019

2. Hepatoprotective potential of standardized Ficus species in intrahepatic cholestasis rat model: Involvement of nuclear factor-kappa B, and Farnesoid X receptor signaling pathways
   - By: El-hawary, Seham S.; Ali, Zeinab Y.; Younis, Inas Y.
   - JOURNAL OF ETHNOPHARMACOLOGY
   - Volume: 231   Pages: 262-274  Published: MAR 1 2019

3. Novel betulin derivative is responsible for the anticancer folk use of Ziziphus spina-christi from the hot environmental habitat of UAE
   - By: Soliman, Sameh; Hamoda, Alshaimaa M.; El-Shorbagi, Abdel-Nasser A.;
   - et al. JOURNAL OF ETHNOPHARMACOLOGY
   - Volume: 231   Pages: 403-408  Published: MAR 1 2019

4. Discovery of highly potent V600E-B-RAF kinase inhibitors: Molecular modeling study
   - By: Tarazi, Hamadeh; El-Gamal, Mohammed I.; Oh, Chang-Hyun
   - BIOORGANIC & MEDICINAL CHEMISTRY
   - Volume: 27   Issue: 4   Pages: 655-663   Published: FEB 15 2019

5. Synthesis and anti-HCV activity of beta-D-2 '-deoxy-2 '-alpha-chloro-2 '-beta-fluoro and beta-D-2 '-deoxy-2 '-alpha-bromo-2 '-beta-fluoro nucleosides and their phosphoramidate prodrugs
   - By: Ovadia, Reuben; Khalil, Ahmed; Li, Hao;
   - et al. BIOORGANIC & MEDICINAL CHEMISTRY
   - Volume: 27   Issue: 4   Pages: 664-676   Published: FEB 15 2019

6. Development of novel liver X receptor modulators based on a 1,2,4-triazole scaffold
   - By: Goher, Shaimaa S.; Griffett, Kristine; Hegazy, Lamees;
   - et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
   - Volume: 29   Issue: 3  Pages: 449-453   Published: FEB 1 2019

7. Green synthesis, antileishmanial activity evaluation, and in silico studies of new amino acid-coupled 1,2,4-triazoles
   - By: El-Saghier, Ahmed M.; Mohamed, Mounier A.; Abd-Allah, Omyma A.;
   - et al. MEDICINAL CHEMISTRY RESEARCH
   - Volume: 28   Issue: 2   Pages: 169-181   Published: FEB 2019

8. Syntheses and in silico pharmacokinetic predictions of glycosylhydrazinyl-pyrazolo[1,5-c]pyrimidines and pyrazolo[1,5-c]triazolo[4,3-a]pyrimidines as anti-proliferative agents
   - By: Atta, Kamal F. M.; Farahat, Omaima O. M.; Al-Shargabi, Tareq Q.;
   - et al MEDICINAL CHEMISTRY RESEARCH
   - Volume: 28   Issue: 2   Pages: 215-227   Published: FEB 2019

9. New secondary metabolites from the mangrove-derived fungus Aspergillus sp. AV-2
   - By: Elissawy, Ahmed M.; Ebada, Sherif S.; Ashour, Mohamed L.;
   - et al. PHYTOCHEMISTRY LETTERS
   - Volume: 29   Pages: 1-5   Published: FEB 2019

10. Anti-inflammatory metabolites from endophytic fungus Fusarium sp
    - By: Khayat, Maan T.; Ibrahim, Sabrin R. M.; Mohamed, Gamal A.;
    - et al. PHYTOCHEMISTRY LETTERS
    - Volume: 29   Pages: 104-109   Published: FEB 2019

11. Two New isoquinoline alkaloids from the bark of Alphonsea cylindrica King and their antioxidant activity
    - By: Aldulaimi, Ahmed Kareem Obaid; Azziz, Saripah Salbiah Syed Abdul; Bakri, Yuhanis Mhd;
    - et al. PHYTOCHEMISTRY LETTERS
    - Volume: 29   Pages: 110-114   Published: FEB 2019

12. Flavone C-glycosides from Vaccaria pyramidata: Structure elucidation by spectroscopy and theoretical calculations
    - By: Ben Said, Ridha; Hamed, Arafa, I; Masullo, Milena;
    - et al. PHYTOCHEMISTRY LETTERS
    - Volume: 29   Pages: 119-124   Published: FEB 2019

13. Cytotoxicity of Luffa cylindrica (L.) M.Roem. extract against circulating cancer stem cells in hepatocellular carcinoma
    - By: Abdel-Salam, Ibrahim M.; Awadein, Nihal El-Sayed; Ashour, Mohamed
    - JOURNAL OF ETHNOPHARMACOLOGY
    - Volume: 229   Pages: 89-96   Published: JAN 30 2019

14. Synthetic approaches to isocarbacyclin and analogues as potential neuroprotective agents against ischemic stroke
    - By: Abu Deiab, Ghina'a I.; Croatt, Mitchell P.
    - BIOORGANIC & MEDICINAL CHEMISTRY
    - Volume: 27   Issue: 2   Pages: 338-342   Published: JAN 15 2019

15. Myorelaxant Activity of essential oil from Origanum majorana L. on rat and rabbit
    - By: Makrane, Hanane; Aziz, Mohammed; Berrabah, Mohamed;
    - et al. JOURNAL OF ETHNOPHARMACOLOGY
    - Volume: 228   Pages: 40-49  Published: JAN 10 2019

16. Bacteria Hunt Bacteria through an Intriguing Cyclic Peptide
    - By: Monaim, Shimaa A. H. Abdel; Somboro, Anou M.; El-Faham, Ayman;
    - et al. CHEMMEDCHEM
    - Volume: 14   Issue: 1   Pages: 24-51   Published: JAN 8 2019

17. Application of liquisolid technology for promoting the renoprotective efficacy of walnut extracts in chronic renal failure rat model
    - By: Al-Okbi, Sahar Youssef; Mohamed, Doha Abdou; Named, Thanaa El-Sayed;
    - et al. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
    - Volume: 45   Issue: 1   Pages: 32-42   Published: JAN 2 2019

18. Fabrication of rosuvastatin-loaded polymeric nanocapsules: a promising modality for treating hepatic cancer delineated by apoptotic and cell cycle arrest assessment
    - By: Aldalaen, Saed; El-Gogary, Riham, I; Nasr, Maha
    - DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
    - Volume: 45   Issue: 1   Pages: 55-62   Published: JAN 2 2019

19. The Irrelevance of In Vitro Dissolution in Setting Product Specifications for Drugs Like Dextromethorphan That are Subject to Lysosomal Trapping
    - By: Bolger, Michael B.; Macwan, Joyce S.; Sarfraz, Muhammad;
    - et al. JOURNAL OF PHARMACEUTICAL SCIENCES
    - Volume: 108   Issue: 1   Pages: 268-278   Published: JAN 2019

20. Phytochemical, Anti-diabetic and Cardiovascular Properties of Urtica dioica L. (Urticaceae): A Review
    - By: El Haouari, Mohammed; Rosado, Juan A.
    - MINI-REVIEWS IN MEDICINAL CHEMISTRY
    - Volume: 19   Issue: 1   Pages: 63-71   Published: 2019

21. Synthesis and Antitumor Activity of Novel [1,2,4,5]-tetrazepino[6,7-b]indole Derivatives: Marine Natural Product Hyrtioreticuline C and D Analogues
    - By: Muhammad, Zeinab A.; Radwan, Mohamed A. A.; Farghaly, Thoraya A.;
    - et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
    - Volume: 19   Issue: 1   Pages: 79-86   Published: 2019

22. Design, Synthesis and Biological Evaluation of Spiro Cyclohexane-1,2-Quinazoline Derivatives as Potent Dipeptidyl Peptidase IV Inhibitors
    - By: Syam, Yasmin M.; Abd El-Karim, Somaia S.; Nasr, Tamer;
    - et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
    - Volume: 19   Issue: 3   Pages: 250-269   Published: 2019

23. Recent Advances In Glyoxalase-I Inhibition
    - By: Al-Balas, Qosay A.; Hassan, Mohammad A.; Al-Shar'i, Nizar A.;
    - et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
    - Volume: 19   Issue: 4   Pages: 281-291   Published: 2019

24. Novel pyrazolo[3,4-d]pyrimidines: design, synthesis, anticancer activity, dual EGFR/ErbB2 receptor tyrosine kinases inhibitory activity, effects on cell cycle profile and caspase-3-mediated apoptosis
    - By: Maher, Mai; Kassab, Asmaa E.; Zaher, Ashraf F.;
    - et al. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
    - Volume: 34   Issue: 1   Pages: 532-546   Published: JAN 1 2019

25. Bypassing Glutamic Acid Decarboxylase 1 (Gad1) Induced Craniofacial Defects with a Photoactivatable Translation Blocker Morpholino
    - By: O'Connor, Matthew J.; Beebe, Lindsey L.; Deodato, Davide;
    - et al. ACS CHEMICAL NEUROSCIENCE
    - Volume: 10   Issue: 1   Pages: 266-278   Published: JAN 2019

26. Design, synthesis, and biologic evaluation of novel chrysin derivatives as cytotoxic agents and caspase-3/7 activators
    - By: Al-Oudat, Buthina Abdallah; Alqudah, Mohammad Ali; Audat, Suaad Abdallah;
    - et al. DRUG DESIGN DEVELOPMENT AND THERAPY
    - Volume: 13   Pages: 423-433   Published: 2019

27. Cytotoxicity and mitochondrial-mediated apoptosis induced by Fenugreek seed oil in human hepatocellular carcinoma cells via reactive oxygen species generation
    - By: Al-Sheddi, Ebtesam S.; Farshori, Nida N.; Al-Oqail, Mai M.;
    - et al. PHARMACOGNOSY MAGAZINE
    - Volume: 15   Issue: 60   Pages: 12-17   Published: JAN-MAR 2019

28. Synthesis and antitumor activity evaluation of different 2,5-dialkyloxazolopyrano[3,2-c]quinolinone derivatives
    - By: Hassanin, Hany M.; Abd Elmoneam, Wafaa R.; Mostafa, Mai A.
    - MEDICINAL CHEMISTRY RESEARCH
    - Volume: 28   Issue: 1   Pages: 28-38  Published: JAN 2019

29. Synthesis and antimicrobial evaluation of novel N-substituted 4-ethylsulfanyl-2-pyridones and triazolopyridines
    - By: Azzam, Rasha A.; Elgemeie, Galal H.
    - MEDICINAL CHEMISTRY RESEARCH
    - Volume: 28   Issue: 1   Pages: 62-70  Published: JAN 2019

30. Isolation and Antimicrobial Activity of Rutin and Its Derivatives from Ruta chalepensis (Rutaceae) Growing in Iraq
    - By: Al-Majmaie, Shaymaa; Nahar, Lutfun; Sharples, George P.;
    - et al. RECORDS OF NATURAL PRODUCTS
    - Volume: 13   Issue: 1   Pages: 64-70  Published: JAN-FEB 2019

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